LIU Jianrong
Chemistry Lecturer
Courses: Advanced Chemistry and Advanced Chemistry Experiment
Email: liujianrong2017@126.com
Research experience:
2013-2016: UMR990 INSERM/University of Auvergne, Clermont-Ferrand, France
PhD student, Development of fluorinated radioligands for PET imaging of Phosphodiesterase 5 in brain
Project included mainly organic synthesis, and also radiosynthesis and biological tests
Collaboration with HZDR Site Leipzig (Worked twice of four weeks in Leipzig Laboratory), German
Collaboration with intern students (Co-supervised four students)
2012-2013: Organic Chemistry Researcher, Pharmaron Beijing Co., Ltd., Beijing, China
Design synthetic schemes and revise approaches in the course of research
Multi-steps (8-13 steps) synthesis to produce the final product in small scales (20-50 mg)
2011-2012: Internships Master in UMR990 INSERM/University of Auvergne, Clermont-Ferrand, France
Pharmacomodulation study of a mechanical vector applied to the targeted chemotherapy
Synthesis of cleavable pro-drugs in hypoxic environment: Applications in metastasized melanoma
Education:
2013-2016: PhD: Pharmacochemistry, University of Auvergne, Clermont-Ferrand, France
Funded by China Scholarship Council
2010-2012: Master: Science of Medicament, University of Auvergne & University of Blaise Pascal, Clermont-Ferrand, France
Conception, Synthesis and Pharmaceutical Development (Chemistry course)
2009-2010: French leaning, L’Alliance française de Xi’an, China
2005-2009: Bachelor of Pharmaceutical Science and Engineering, Northwest University, Xi’an, China
Approved Research Grants (Principal Investigator)
1. Project Title: Mechanism Study of Marine Natural Active Molecule Baculiferin in Anti-HIV Based on Photoaffinity Small-Molecule Probe Technology
o Funding Agency: National Natural Science Foundation of China (NSFC)
o Project Type: Young Scientists Fund Project
o Project No.: 81803424
o Period: Jan. 2019 – Dec. 2020
o Funding Amount: 189,100 yuan
2. Project Title: Target Identification of Aaptamine-Type Marine Alkaloids Using Photoaffinity Labeling Technology
o Funding Agency: Beijing Municipal Natural Science Foundation
o Project Type: General Program
o Project No.: 7202090
o Period: Jan. 2020 – Dec. 2021
o Funding Amount: 200,000 yuan
3. Project Title: Structure-Activity Relationship and Mechanism Study of Novel Anti-HIV Marine Alkaloid Baculiferins
o Funding Agency: China Postdoctoral Science Foundation
o Project Type: General Program
o Project No.: 2017M620540
o Period: Jan. 2017 – Dec. 2019
o Funding Amount: 50,000 yuan
Publications:
Jianrong Liu，Ronan Feneux, Gauthier Roisine, Zhongrui Chen, Guide d’enseignement expérimental pour le professeur de Chimie, Shanghai, Shanghai JIAO TONG UNIVERSITY PRESS, 2024, ISBN 978-7-313-29981-9
Jianrong Liu, Ling Ma, Chang Song, Hui Xing, Shan Cen, Wenhan Lin, Anti-HIV Effects of Baculiferins Are Regulated by the Potential Target Protein DARS, ACS Chem. Biol. 2021, 16, 1377-1389
Siwen Niu, Dong Liu, Zongze Shao, Jianrong Liu, Aili Fan, Wenhan Lin, Chemical epigenetic manipulation triggers the production of sesquiterpenes from the deep-sea derived Eutypella fungus, Phytochemistry, 2021, 192, 112978
Jianrong Liu; Aurélie Maisonial-Besset; Barbara Wenzel; Damien Canitrot; Ariane Baufond;Jean-Michel Chezal; Peter Brust; Emmanuel Moreau ; Synthesis and in vitro evaluation of new fluorinated quinoline derivatives with high affinity for PDE5: Towards the development of new PETneuroimaging probes, European Journal of Medicinal Chemistry, 2017, 136: 548-560
J.R. Liu, B. Wenzel, S. Dukic-Stefanovic, R. Teodoro, F.A. Ludwig, W. Deuther-Conrad, S. Schröder, J.M. Chezal, E. Moreau, P. Brust, and A.
Maisonial-Besset; Development of a new radiofluorinated quinoline analog for PET imaging of phosphodiesterase 5 (PDE5) in brain;
Pharmaceuticals; 2016, 9, 22; doi:10.3390/ph9020022
R. El Aissi, J.R. Liu, S. Besse, J.M. Chezal, D. Canitrot, O. Chavignon, E. Miot-Noirault, E. Moreau; Synthesis and Biological Evaluation of New Quinoxaline Derivatives of ICF01012 as Melanoma-Targeting Probes; Medicinal Chemistry Letters; 2014, 5, 468-473; dx.doi.org/10.1021/ml400468x
J.R. Liu, B. Wenzel, S. Dukic-Stefanovic, R. Teodoro, F.A. Ludwig, W. Deuther-Conrad, S. Schröder, J.M. Chezal, E. Moreau, P. Brust, and A. Maisonial-Besset; Design,
synthesis, radiosynthesis, and biological evaluation of radiofluorinated quinoline derivatives for PET imaging of PDE5A in brain; EFMC International Symposium on
Medicinal Chemistry; 28 August-01 September 2016, Manchester UK, Poster 082
