LIU Jianrong
Chemistry Lecturer
Courses: Advanced Chemistry Experiment
Email: liujianrong2005@163.com
Research experience:
2013-2016: UMR990 INSERM/University of Auvergne, Clermont-Ferrand, France
PhD student, Development of fluorinated radioligands for PET imaging of Phosphodiesterase 5 in brain
Project included mainly organic synthesis, and also radiosynthesis and biological tests
Collaboration with HZDR Site Leipzig (Worked twice of four weeks in Leipzig Laboratory), German
Collaboration with intern students (Co-supervised four students)
2012-2013: Organic Chemistry Researcher, Pharmaron Beijing Co., Ltd., Beijing, China
Design synthetic schemes and revise approaches in the course of research
Multi-steps (8-13 steps) synthesis to produce the final product in small scales (20-50 mg)
2011-2012: Internships Master in UMR990 INSERM/University of Auvergne, Clermont-Ferrand, France
Pharmacomodulation study of a mechanical vector applied to the targeted chemotherapy
Synthesis of cleavable pro-drugs in hypoxic environment: Applications in metastasized melanoma
Education:
2013-2016: PhD: Pharmacochemistry, University of Auvergne, Clermont-Ferrand, France
Funded by China Scholarship Council
2010-2012: Master: Science of Medicament, University of Auvergne & University of Blaise Pascal,
Clermont-Ferrand, France
Conception, Synthesis and Pharmaceutical Development (Chemistry course)
2009-2010: French leaning, L’Alliance française de Xi’an, China
2005-2009: Bachelor of Pharmaceutical Science and Engineering, Northwest University, Xi’an, China
Publications:
J.R. Liu, B. Wenzel, S. Dukic-Stefanovic, R. Teodoro, F.A. Ludwig, W. Deuther-Conrad, S. Schröder, J.M. Chezal, E. Moreau, P. Brust, and A.
Maisonial-Besset; Development of a new radiofluorinated quinoline analog for PET imaging of phosphodiesterase 5 (PDE5) in brain;
Pharmaceuticals; 2016, 9, 22; doi:10.3390/ph9020022
R. El Aissi, J.R. Liu, S. Besse, J.M. Chezal, D. Canitrot, O. Chavignon, E. Miot-Noirault, E. Moreau; Synthesis and Biological Evaluation of New
Quinoxaline Derivatives of ICF01012 as Melanoma-Targeting Probes; Medicinal Chemistry Letters; 2014, 5, 468-473; dx.doi.org/10.1021/ml400468x
J.R. Liu, B. Wenzel, S. Dukic-Stefanovic, R. Teodoro, F.A. Ludwig, W. Deuther-Conrad, S. Schröder, J.M. Chezal, E. Moreau, P. Brust, and A. Maisonial-Besset; Design,
synthesis, radiosynthesis, and biological evaluation of radiofluorinated quinoline derivatives for PET imaging of PDE5A in brain; EFMC International Symposium on
Medicinal Chemistry; 28 August-01 September 2016, Manchester UK, Poster 082
